Which of the following is a manifestation of Cushing's syndrome?

A manifestation of Cushing's syndrome is characterized by the accumulation of abnormal amounts of cortisol in the body, which leads to several distinct physical signs. Moon face, a rounding of the face, is one of the classic features associated with this condition. This occurs due to the redistribution of body fat and water retention caused by elevated cortisol levels.

In addition to moon face, other manifestations of Cushing's syndrome include weight gain, especially in the trunk and abdomen, thinning of the skin, and easy bruising. Hirsutism, while it can occur in Cushing's syndrome due to increased adrenal androgens, is not as universally recognized as the moon face, which is often seen as a classic symptom.

Intention tremors and Brudzinski's sign are not related to Cushing's syndrome. Intention tremors are usually associated with neurological conditions affecting coordination, while Brudzinski's sign is indicative of meningeal irritation or potential meningitis. Therefore, recognizing moon face as a manifestation of Cushing's syndrome highlights its clinical significance in diagnosis and monitoring of this endocrine disorder.